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CO-45 Denial Code: What It Means, Causes & How to Resolve It [2026]

The CO-45 denial code appears on more remittance advices than almost any other adjustment code in medical billing. It’s not a denial in the way most people think. Your claim was processed and paid; CO-45 just documents the gap between what you billed and what your payer contract allows. According to the AMA’s National Health […]

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