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CPT Code 78452: The 2026 Billing Guide to SPECT Myocardial Perfusion Imaging

CPT code 78452 nuclear stress test billing 2026 hero banner: SPECT multiple-study rest-and-stress protocol versus 78451 single phase, 78453 and 78454 for planar not SPECT, 78491 and 78492 for PET not 78452, MAC-specific LCD coverage under NGS A56743 and Novitas, Lexiscan J2785 and Cardiolite A9500 billed separately, and nuclear medicine certification required for the interpreting physician, from One O Seven RCM.

What Is CPT Code 78452, and Which Modality Does It Cover CPT code 78452 reports myocardial perfusion imaging using SPECT technology, performed as multiple studies, both rest and stress, to evaluate blood flow to the heart muscle and identify areas of reduced perfusion. Physicians order this study to diagnose coronary artery disease, evaluate damage after […]

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